Predicting Cancer Drug Response: Advancing the DREAM

Predicting cancer drug response: advancing the DREAM.

The DREAM challenge is a community effort to assess current capabilities in systems biology. Two recent challenges focus on cancer cell drug sensitivity and drug synergism, and highlight strengths and weaknesses of current approaches.

Predicting cancer drug response by proteomic profiling.

PURPOSE Accurate prediction of an individual patient's drug response is an important prerequisite of personalized medicine. Recent pharmacogenomics research in chemosensitivity prediction has studied the gene-drug correlation based on transcriptional profiling. However, proteomic profiling will more directly solve the current functional and pharmacologic problems. We sought to determine whether...

Chemistry. Chemistry in a computer: advancing the in silico dream.

To dream the maybe possible dream: a breast cancer vaccine.

Advancing the drug discovery and development process.

The current state of affairs in the drug discovery and development process is briefly summarized and then ways to take advantage of the ever-increasing fundamental knowledge and technical knowhow in chemistry and biology and related disciplines are discussed. The primary motivation of this Essay is to celebrate the great achievements of chemistry, biology, and medicine and to inform and inspire...